| Criteria | Article 1 | Article 2 | Article 3 |
| APA-Formatted Article Citation with Permalink | Bloom, L., Boyle, K. E., Myers, A. E., Blacketer, C., & Weinstein, R. (2019). Frequency of nonaspirin NSAID-relevant coexisting medical conditions in the primary-care setting: A retrospective database review. Therapeutics and Clinical Risk Management,Volume 15, 579-588. doi:10.2147/tcrm.s189833
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Lai, K. M., Chen, T., Chang, C., Chen, H., & Lee, Y. (2019). Association between NSAID use and mortality risk in patients with end-stage renal disease: A population-based cohort study. Clinical Epidemiology,Volume 11, 429-441. doi:10.2147/clep.s204322
Qualitative and quantitative research critique and ethical considerations and Literature Evaluation Table
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Gawande, A., Gupta, G. K., Gupta, A., Wanjari, S. J., Goel, V., Rathore, V., . . . Nijhawan, S. (2019). Acute-on-Chronic Liver Failure: Etiology of Chronic and Acute Precipitating Factors and Their Effect on Mortality. Journal of Clinical and Experimental Hepatology. doi:10.1016/j.jceh.2019.04.050
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| How Does the Article Relate to the PICOT Question? | It researches on use of NSAID with coexisting conditions. | It researches the use of NSAID and mortality rates with CKD patients | Prevalence of acute on chronic liver failure, underlying etiology and precipitating factors.
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| Quantitative, Qualitative (How do you know?) | Qualitative | Qualitative | Quantitative |
| Purpose Statement | To find the effects of NSAID with coexisting conditions.
Qualitative and quantitative research critique and ethical considerations and Literature Evaluation Table |
investigate the association between the use of NSAIDs and the risk of mortality in patients with end-stage renal disease.
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| Research Question | Frequency of non-aspirin NSAID-relevant coexisting medical conditions in the primary-care setting
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Association between NSAID use and mortality risk in patients with end-stage renal disease: a population-based cohort study
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Estimating the prevalence of acute on chronic liver failure in our institute, etiology of underlying chronic liver disease, precipitating acute event and mortality rate.
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| Outcome | the prevalence of renal disease was low in all three databases | In the study cohort, 2,623 (78%) patients used NSAIDs during the follow-up period. The median follow-up period was 4.0 years, during which 1,515 patients died. The results of multivariable analysis demonstrated that compared with NSAID nonuse, the use of any NSAIDs, nonselective NSAIDs, and selective cyclooxygenase-2 inhibitors was associated with a significantly increased risk of all-cause mortality
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Out of 386 patients, 150 patients were admitted with acute on chronic liver failure with a prevalence of 39%. In 41% of patients, infection was the precipitating factor for ACLF either in the form of Sepsis, spontaneous bacterial peritonitis, Lower respiratory tract infection or skin, and soft tissue infections. Alcohol was the second most precipitating factor (32%), followed by upper gastrointestinal hemorrhage (12%) and drugs (2%).
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| Where did the study take place? | USA | Taiwan | Rajiv Gandhi Government General Hospital
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| Sample | Patients aged ≥18 years in 2013 with a visit to a PCP in the same year were included in the study. Only patients with ≥1 year of enrollment prior to their first PCP visit in 2013 were included, so that medical history was available to review.
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A total of 3
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